Computational Epitope Prediction and Screening Precision Antibody Therapeutics for Alzheimer's Disease

Current State of Alzheimers Disease Research Therapeutics

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Computational drug repositioning for peripheral arterial disease: prediction of anti-inflammatory and pro-angiogenic therapeutics

Peripheral arterial disease (PAD) results from atherosclerosis that leads to blocked arteries and reduced blood flow, most commonly in the arteries of the legs. PAD clinical trials to induce angiogenesis to improve blood flow conducted in the last decade have not succeeded. We have recently constructed PADPIN, protein-protein interaction network (PIN) of PAD, and here we combine it with the dru...

prediction of linear and conformational b cell epitope of her2 ecd for monoclonal antibody development using immunoinformatic methods

Antibody Engineering and Therapeutics

note: The views expressed herein are those of the authors and do not necessarily reflect the views of their respective employers. Speakers who wrote a summary of their own presentation are listed in the header for the relevant session. The majority of the other summaries in this report were based on PDFs of the presentations provided by speakers or on post-meeting input from the speakers. The a...

Magnesium and Alzheimers Disease: The Cholinergic Hypothesis

The cholinergic deficit in Alzheimer’s disease (AD) remains the cornerstone for the understanding of chemical signal transfer. Hypofunctions of cholinergic systems are significantly involved in the signs and symptoms of senile dementia of the Alzheimer type. Cognitive deficits in AD have been widely associated with dysfunction of the cholinergic system. As a diagnostic marker of AD the activity...